Answering Questions Research Paper Example | Topics and Well Written Essays - 500 words - 12

Answering Questions - Research Paper Example Hogan is incredibly light in her touch in connecting these ideas, relying on the inbuilt notions of her reader more than her own prowess. Answer: Hogan’s tone is incredibly personal, and she tries to bring out the magic of her subjects to give a sense of wonder to her reader. She starts out by being incredibly personal, telling about her own life, which helps build a report and avoids any stilted formality. She then moves on, however, to connect her life to the wonders of the cosmos in the form of the voyager space craft, expanding her vocabulary and putting herself in the context of the wider universe. She thus minimizes both herself and her reader, asking them to see themselves in the context of the wonder of the universe. Answer: I think that it is a natural human impulse to put our best foot forward, and in that way we were somewhat honest to ourselves in leaving some things out. We sent this to be a craft that was supposed to demonstrate who humans want to be, the best of our capabilities, not the worst. To answer this question, ask yourself if it would be wise to tell a stranger the best and worst things about you all at once when you first meet them. In any society on the planet Earth, the answer would be a definitive no. We were being honest to who we are: people who want the universe to think well of us. Finally, putting the bad in with the good might codify the bad: make the bad okay, normal, who we

Essay --

Apollo 13 experiences major malfunctions which end up changing the mission from landing on the moon to now just trying to return to earth with all of the crew still alive. This movie illustrates how the leaders can develop a new vision and values, and how the team can come together and collaborate under high stress situations. Their vision changes from landing the astronauts on the moon to just getting the astronauts back to earth safely when there is an unexpected explosion in the service module. Even under a ridiculous amount of pressure, the crew was able to communicate efficiently and use their decision making skills to help solve the problem effectively. Apollo 13 is all about how their team effort and leadership skills come together to overcome what they thought would be a horrifying ending. Gene Kranz who was the flight director and in charge of the mission control team, developed a set of values; discipline, morale, toughness, competence, commitment, and team work to approach the situation. These set of values helped build the chemistry that kept them together during all of the different difficulties that had to face and helped the reach success in the end. For every seemingly impossible situation, Mr. Kranz gives new liveliness and vision to the team by his response always being â€Å"we need to find a way to make it work.† His leadership focuses on path goal theory. During his meetings when they were trying to develop a re-entry plan, he was only worried about making sure they were taking the right steps to bring the astronauts back safely. He explains to his colleagues what the proposals are, considers new thoughts, and is very supportive of everyone’s ideas. He clarifies the main goal and uses his relationship with everyon... ... go well and end safely. Marilyn displays personal integrity when she demands to know what is going on with the mission after she sees the news report on TV. She shows self-confidence when she calls and demands to know what’s going on and is will not hang up until she gets answers. During the whole situation she holds herself together under all of the stress, showing her emotional maturity. Gene Kranz and Jim Lovell are the main people who show how a leader is able to influence and lead the team when an unexpected situation occurs. When they’re having to face issues, conflicts, and achieving goals, making sure that your crew is focused is very important. No matter what pressure or conflict they were dealing with, they were able to make decisions fast and effectively. The leadership and team structure were the main reasons behind the ground team’s incredible work.

Development of Anti-Idiotype Vaccine for Human Follicular Lymphoma

Non-Hodgkin’s lymphomas (NHL) constitute a heterogeneous group of malignancies whose incidence has significantly increased in recent decades. In the year 2000, more than 145,000 cases of NHL were diagnosed in developed countries, representing thus the sixth most common cancer occurring among men and the eighth among women. Low-grade B-cell NHLs, in particular, are incurable diseases characterized by relatively slow growth and excellent initial responsiveness to chemotherapy but also by continuous relapses. In particular, for patients with follicular lymphoma, median overall survival (7-10 years) has not improved over the past 30 years. Although in the vast majority of patients complete or partial remissions can be obtained with either single agents or combination chemotherapy, the clinical course is characterized by a high relapse rate. After relapse, both the response rate and relapse-free survival after subsequent salvage treatment regimens steadily decrease, resulting in a median survival of only 4-5 years after the first relapse. These clinical findings, coupled with the substantial toxicities of standard treatments, have stimulated the search for novel and more tumor-selective therapies.Follicular lymphoma is a clonal B cell malignancy that expresses a unique antigen that is formed by the immunoglobulin light and heavy chains that possess highly variable regions at their amino termini. These variable regions combine to form the antigen recognition site, which can itself be recognized as an antigen, termed the idiotype. The antigen-binding site is a structural feature of each immunoglobulin that distinguishes it from other immunoglobulins. The idiotype of a particular clonal B cell lymphoma represents a tumor-specific antigen. Idiotype is a target of interest in human lymphoma.Therapeutic vaccines targeting B cell lymphoma idiotype (Id) represent a promising immunotherapeutic approach for a better clinical control of these malignancies.Immunoglobulin (Ig) molecules are composed of heavy and light chains that possess highly variable regions at their amino termini. B-cell malignancies are clonal proliferations of Ig-producing cells. The idiotypic determinants of the surface Ig can thus serve as a tumor-specific marker for the malignant clone.Indeed, both protein- and dendritic cell-based vaccines that use the patient-specific Id have resulted in clinically significant tumor-specific cellular responses with very little toxicity. A broad use of Id-based vaccination for B cell lymphomas, however, is hampered by the fact that these approaches are patient-specific so that the vaccine must be individually produced for each patient. On these grounds, new strategies obviating the need to produce customized vaccines would further simplify clinical applications of idiotypic vaccines.Goals:Goal 1:Establishment of a large database including sequences of idiotypic VH and VL genes expressed by a variety of lymphoproliferative disorders, includ ing low grade B-NHL, autoimmunity-associated lymphoproliferations, and chronic lymphocytic leukemia. This will allow the identification of candidate Id proteins for â€Å"cross-reactive† immunotherapy.Goal 2:Pre-clinical characterization of the immunogenicity of selected natural Id proteins, with particular regard to their ability to induce immune responses against lymphoma cells expressing molecularly correlated Id proteins. The characterization will include the identification of B cell epitopes and HLA Class I-restricted cytotoxic T cell epitopes using innovative approaches and will allow the development of dedicated assays for immunomonitoring.Goal 3:Design and validation of optimized Id vaccine.Goal 4:Evaluation and validation of new adjuvants and innovative delivery systems for improved Id vaccine formulations and administration.Goal 5:â€Å"Clinical-grade† production and purification of optimized Id proteins for patient vaccination.IntroductionThere are approxima tely 65,000 new cases of non-Hodgkin’s lymphoma diagnosed each year in the US with a comparable number in Europe. Despite the use of aggressive chemotherapy and recent advances in therapy such as monoclonal antibodies (Rituxan, TM), the disease is almost invariably fatal. Follicular lymphoma (FL) patients, in particular, can have an indolent but ultimately fatal clinical course. The median relapse time for FL patients is three years, with 90% of patients dying of a tumor-related mortality within 7 years of the date of diagnosis.The clinical course is usually characterized by a series of remissions and relapses. Good response rates are seen with treatments such as chemotherapy, radiation, lymphocyte transplantation, and monoclonal antibodies. However, following initial response to treatment, the cancer invariably returns and the majority of patients relapse with resistance to all available therapy. Related B-cell derived neoplasms include multiple myeloma (approx. 15,000 cases /year in the US and chronic lymphocytic leukemia (approx. 10,000 cases/year in the US).Isolation of tumor-specific antigens (TSAs) has been a long sought-after goal for scientists involved in both basic and clinical research. Whereas tumor-associated antigens (TAAs) are localized on both normal and tumor cells, TSA are peculiar to tumor cells. This characteristic makes TSA a very desirable target for immune therapy strategies aiming to spare normal cells, or at least the indispensable ones.As regards effectors mechanisms, although some indirect evidence exists for participation of both natural killer (NK) cells (especially those activated by IL-2, known as lymphokine- activated killer, or LAK cells), and TNF-secreting macrophages in tumor immunity, most interest has been focused on the role of antigen-specific antibodies and T lymphocytes. This is particularly true among scientists developing anti-Id vaccines for human FL, even though no substantial agreement has yet been reached on which of the two main effectors pathways is most important.FL conforms to the general rule that tumors have several mechanisms to escape the attention of the immune system. The risks that Ig somatic hypermutations could result in aminoacid residue replacements leading to substantial changes within the fine immunogenic structure of the Id do not seem to be so relevant. Indeed, no such occurrence has been reported in any of the several dozen patients who have been immunized over the last decade. A much more relevant issue is the very limited ability of FL cells to present their own antigens.Although ontogenetically very close to normal mature B-lymphocytes, with respect to their normal counterparts FL cells are very poor as antigen presenting cells (APCs). This makes it rather difficult to evaluate any vaccine-induced, tumor-specific cytotoxicity even in vitro. On the other hand, no such problems exist for ELISA-based detection of the tumor-specific and vaccine-induced humoral respon se.The first study of anti-Id vaccinations in humans dates only from 1992. Until then, all the work had obviously been confined to animal models. However, the accumulation of experimental data has led to the development of several promising strategies that are currently being investigated in clinical trials. These include the utilization of the Id in the form of a soluble protein or as a DNA sequence, either used to pulse dendritic cells (DCs) or else to be administered in combination with immunologic adjuvants.Soluble protein Id vaccine production is based on a hybridoma technique, which in vitro allows production of exactly the same Ig as that present on the surface of the clonal B cells of FL, or in other words the tumor-specific Id. The suspension of single cells obtained from a biopsy specimen almost invariably contains a residual population of normal B-lymphocytes alongside the tumor cells. Screening of the hybridomas by means of Ig heavy chain CDR3 PCR identification is there fore required in order to make sure that the Ig of the selected hybridoma is truly identical to the tumor- associated one.31 Once the cultured hybridoma has yielded enough purified Id, the TSA needs to be made far more immunogenic than it is in its free form. For this purpose, it may either be conjugated with a highly immunogenic carrier such as keyhole limpet hemocyanin (KLH), or else used to pulse autologous DCs.The association of a soluble protein Id vaccine with immunologic adjuvants monocyte colony-stimulating-has also proved extremely important. Granulocyte factor (GM-CSF) currently seems to be the best such adjuvant both in animal models and humans, probably because of its capacity for local recruitment of DCs in vivo at the site of vaccine injections. This step would appear to be superfluous when autologous DCs are loaded with Id ex vivo and then re-injected into the patient.A completely different alternative approach involves administration of the patients’ Id-encodi ng DNA sequence. With the rise of molecular technology, such DNA vaccines are beginning to come into their own. For instance, exploitation of appropriate molecular vectors (ie containing both a leader and promoter sequence) for insertion of the nucleotide sequences responsible for biosynthesis of both the Ig heavy and light chains variable regions is now relatively easy.Between the heavy- and light-chains variable regions sequences, an intertwined linker peptide must also be inserted to allow the ultimate Id-containing molecule (scFv) to fold properly. Furthermore, the vaccine can be further strengthened by adding other DNA sequences encoding for immunologic adjuvants or powerful immunogens to the vector. Finally, intramuscular injections allow progressive release of the Id following synthesis by muscular cells. In addition, this administration route seems to be associated with prolonged conservation of the genetic information within the cells without any apparent signs of integrati on into their genome.Experimental DesignGoal 1:Establishment of a large database including sequences of idiotypic VH and VL genes expressed by a variety of lymphoproliferative disorders, including low grade B-NHL, autoimmunity-associated lymphoproliferations, and chronic lymphocytic leukemia. This will allow the identification of candidate Id proteins for â€Å"cross-reactive† immunotherapy.In establishing a database, there will be steps to follow in order to support the evidences claimed.I. Finding the cases and the occurrence of VH and VL in lymphoproliferative disorders in different hospitals and institutions that could provide valuable information for the said disorders. The facts and information should have the confirmed consent of the persons involved.II. Subjecting the cases to thorough analysis to provide the essential information needed in documenting the cases.III.   Testing the subject under the identification of Id proteins.IV. Organizing the information and est ablishing the database.Methods:Establishing a database to easily organize information and data needed in making the information available readily whenever they will analyze situation in which there is a suspected occurrence of lymphoproliferative disorder. By providing the information needed, they could develop system that would make things easier for them to do actions required in addressing such situation.Primary step is consolidating all the available facts and information provided that they have the consent from the owner of the information. By having the desired facts available for the reorganization of it, they could classify it according to the general category they want to use in creating their database. It could be based on severity of the case or could be base on gender or any factor that could greatly affect the situation.Then, by gathering the information they needed, the analysis of the data should be carefully done for them to eliminate excess and negligible data for a n easier organization of the structure of their available resources. By implicating the main thrust of the database to the core concept of having advance cases of NHL, the higher chance they could get the information and the data based on the clinical findings of actual patients and people who suffered from that.By simply opening the way of introducing different vaccines in addressing the situation, they could develop a system of transferring and managing information that could make things easier especially in developing new technology and medicinal advancement in creating a better and more effective ways of treating such disease. By making the information more manageable, they could likely innovate an advance communication that would lead them in establishing better information and data management for the use of the development of vaccines and cures.Since they have the information but they should examine carefully every bit of information that will be a part of their set of data an d facts. By looking closely to the subjects result and the specification of the action done, the development of such process in introducing a new finding on the matter should be considered. Since the goal is to establish a database that will focus on the information that could provide the facts needed on the cases diagnosed with a NHL, it is important to screen the cases as important and not negligible for them to be able to use it as a case.At the end of the process, they would go back to their primary goal and that is to establish a functional database that the core information and the key factors are integrated in a way that it would make the processing of facts and vital data would be efficient and effectively handled.Also, it will introduce technology that would compensate the fast rising of development in technological advancement even in the field of medicine. Because there are ready to use valuable information for them to handle and initialize their desired action, they woul d be able to commend the different opportunities in which they could get specimens and studied it for future discoveries and researches.In all, by their incorporation of the cases of NHL and their desired goal of making the information available for them to be able to easily study and review the situations and cases they previously have for them to execute and evaluate the validity of the existing tests in the current occurrence of the disease in the real place.Goal 2:Pre-clinical characterization of the immunogenicity of selected natural Id proteins, with particular regard to their ability to induce immune responses against lymphoma cells expressing molecularly correlated Id proteins. The characterization will include the identification of B cell epitopes and HLA Class I-restricted cytotoxic T cell epitopes using innovative approaches and will allow the development of dedicated assays for immunomonitoring.In dealing with the pre-classification of the immunogenicity of selected natu ral Id proteins, the processes involved are:I.   Accumulating soluble proteins to be tested.II. Testing them with hybridoma essential in testing the equivalence of the tumor inducing material that leads to development of the tumor.III.   Inducing the effect of the proteins and identifying its effect on B cells.IV. Using advance technique in analyzing the result and implicating with the use of the modern testing equipment and processes.Accumulation:Testing the proteins for it to be classified will be the first step. From the patients who are suffering from FL, different samples will be getting for the medical technology to be applied. Then by cultivating natural proteins, they will use it to further test the capacity of the natural cell in penetrating and deeply interacting with other Id proteins in the development of resistance to such substance.By eradicating some external factors such as the presence of other organisms, they could screen the protein level for them to be able t o produce and test the Id proteins by exposing it to toxoids that could develop resistance on the desired solution. Then, the Id proteins gathered will be stored for further testing.Testing:Then, preparation of the Id protein to be tested will be carefully done in a controlled environment. Since the tumor development can not be detected by the immune system, the development of inducing material will be necessary for them to penetrate the basic defenses of the tumor.By exposing it to NKL, tumor will exhibit a different behavior but will not be extinguished. Since B cells epitope derived multiply myeloma that had been the major cause of the return of the behavior of the tumor cells, the gradual exposing it to be classified by soluble Id proteins will be dedicated.The allowance of certain percent productivity will be the basic goal of the clinical testing for them to be able to derive the pre-classification scheme that will determine substances that induce immunity on certain level wit h the use of soluble and Id protein present in the environment.Effect and its IdentificationAfter the testing had been carefully done, they will examine its effect on various elemental positions by trying the substance on the possible outcome. Then, FL cells will be isolated then proteins will be added to see the effect on the neoplasms produced by B-cells. Since the outcome would produce certain behavior that will exhibit a different expected one, the process will be repeatedly associated with soluble proteins to target the development of TSA since it target tumor cells.Analyzing the ResultThen, the result will be analyzed in a way that it consistently produces same output. Then after looking closely and making sure that no other substance induced the effect, the validity of the result will be the next concern in analyzing the data. For it to be valuabe, the result should consist the scientific analysis of the vaccine to be introduced for them to be able to adopt a real one.Goal 3: Design and validation of optimized Id vaccine.Since the protein had been introduced in TSA that would target tumor cells, it is important to develop the next stage wherein it will pay attention to that. Tumor cells, after being extinguished by some other methods, always come back and provide a worse situation that before. It is a common problem of the development of cure because as soon as they introduce stronger antigens and antibiotics, the cells develop stronger immunity to them, making them more powerful and gave them the power to come back and come back whenever they are defeated.The result of the previous testing of the material will be used as the raw data in determining the precise development of the vaccine needed for the tumor cells. Toxoids produced by microorganisms will be introduced to the tumor cells for them to create an astounding reaction with the cells to help the antigens produce a better shield to the tumor cells.They would also address the production of its own immunity by targeting the B cells epitopes produced by the tumor cells for them to be able to weaken the effect of the tumor cells in the body. By simply having the same effect on the cells, they would establish the immunity desired.In addition, since soluble proteins produces amino acid residue, the effect of it to the development of various outgoing tumor cells will be beneficial in the sense that it would catch up the screening proves by a hard core stimulation of heavy chain CDR3 PCR. Then, the use of material that would likely predict the behavior will also introduce for the existing antigen to determine it.Goal 4:Evaluation and validation of new adjuvants and innovative delivery systems for improved Id vaccine formulations and administration.After having the result of the vaccine being tested hand-on on the tumor cells, the activation of the production of antigens will be manipulated for those to be able manage the outcome of the result. By having the systematic chain of micr o toxoids that will enter the entire system of the body, they would likely produce different kinds of reactions that would benefit the production of self stimulating antigens.By exposing it to different procedures that would attest the certainty and validity of the desired production, after introducing different sets of toxoids and NK cells, the development of the self inducing multiple protein will help in eradicating the symptoms and the effect of FL.It is known that FL is fatal in terms of its effect on the human entire system. So it is important to devise a precise way of handling and dealing with it for them to be able to have an outer perspective of the natural phenomena.Id proteins will act as binders to the solutions that will be used in strengthening NK cells and TSA to promote the development and inhibit the further production of malignant development of tumor cells. By preventing the further growth of it, they would have larger revenue in which they could satisfy the need s and the improvement for having a stronger antigen.Then, natural growth of TSA will be affected by the inducing of soluble protein to target dendritic cells for them to be able to manifest the basic function of fighting foreign toxins that could affect the development of the tumor as a vital implication of the vaccine. The use of different methods in determining the feasibility of inducing the growth and the development of natural antigens that would be sufficient enough to fight the invading tumor cells will be of great use for them to be able t produce more antigens that will prevent the further worsening of the situation.Validating the use f the vaccine as one of the potential sources of defense against the foreign material invading the system would be beneficial if the could handle the needs of having a more systematized and organized level of founding a solution that would focus on the elimination of cell processes that inhibits the growth of malignant tumor like FL that is fa tal to humans.Subjecting enough NK cells to further strengthening process will help them in making the process worthwhile I making a protein Id that would address the situation as founding solution to the antigen development.Goal 5:â€Å"Clinical-grade† production and purification of optimized Id proteins for patient vaccination.After developing the vaccine the process would involve the following:I.   Purifying the Vaccine to be prepared.II.   Final VerificationIII. Mass ProductionIV.   Patient VaccinationPurificationAfter devising the vaccine, the next step is purifying it by eliminating microorganisms that would have effects on the vaccine. By continuously subjecting the vaccine into different microorganism killing environment, they would lessen the potential of having such. Radiating and constantly developing processes will be sufficient in terminating such microorganisms.Final VerificationAfter the purification of the vaccine, a method will be done for them o be abl e to test if the results are really valid by having it tested for final verification. It is important to deal with it because the importance f verifying the vaccine would greatly affects its validity in the medical society. By having it tested trough lab rats or animals that have developed FL tumors; they would be injected with such vaccine for them to see if the previous results will e the same.Mass ProductionAfter the verification process, the next process will involve producing the vaccine enough for human consumption. The proteins that deal with the development of TSA would have a various report on it validity and essentialism for them to be able to have a developed system of introducing vaccines.VaccinationAfter the production and the vaccine is ready to use, it would be given to the patients, as long as it is approved by the medical board, to be sued as vaccine against the development of FL into malignant tumors that endangered the lives of many people. Then, by having the sys tem of production of certain involvement of the NK cells within the hybridoma of dendritic cells, the vaccine will be of much use since it will introduce antigens that will prepare the body for the possible FL development.Since there are certain kinds of toxoids that will be introduced, there will be a harsh reaction at first to the place where it is injected because of the behavior of the toxoids and the T cells of the body. This is a sign that the vaccine is effective and doing a reaction that would strengthen the immune system of the body.DiscussionAfter the development of the vaccine in FL, it is important to understand the need of developing such because of its adverse effect on the development of humans. It endangered the lives of many people without having the prior notification of the said disease. This is a vital step in the clinical world.Considering the existence of the natural antigens present in the environment, by the use of Id proteins that inhibits the growth of tumo r cells; it would be beneficial to mankind if the continuous development will take place. By exploring the kind of the interaction ventured in this kind of process, the elemental composition of the vaccine would be developed to address the needs of the people in having the desired implication of the subject process.The processing of vaccine would include the development of stages in which it would acknowledge the presence of the cells responsible for the development of the disease. In effect, they would have a better understanding on the subject, matter and would increase the possibility of having a curable state.By implicating the notion of having a different technique in addressing the development of the vaccine, the question left for it is how long would it last for them not only to develop vaccine but also to develop a cure that would forever block the negative effects of the disease. By using and ensuring the safety of the user, they would have a proper citation of the needed p lan for them to be able to execute the importance of the vaccine and its use in the modern life.Furthermore, by examining the application of the vaccine in the curing of the disease, we would see the importance of development and use of innovating techniques in determining the possible outcome of the curing of the disease.Finally, the consideration of the process if it fits the standards of the medical consideration despite the fact that there exist different processes that involve much medicinal advancement should take into consideration the impact of the introduction of this vaccine prior to the ethical understanding of the matter.   Since FL can be considered as one of the deadliest disease that one can have, the help of having a vaccine against it is beneficial to the human industry.

Of Mice and Men Essay - 690 Words

Of Mice and Men nbsp;nbsp;nbsp;nbsp;nbsp; During the time of the depression, an author by the name of John Steinbeck wrote a novel called Of Mice and Men. The novel’s setting is in Southern California during the same time period. John Steinbeck shows us that friendship is a valuable thing to have in the novel Of Mice and Men. The book expresses how friendship can get you through hard times and help you keep going. Two of the characters in the novel named George and Lennie, have a relationship that describes the perfect friendship in my opinion. They are always there for each other and always have each others back. nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;George and Lennie and two very different types of people.†¦show more content†¦George also help Lennie get his job on the ranch by using his intelligence and telling the boss,† He can do anything you tell him. He’s a good skinner, he can rassel grain bags, drive a cultivator. He can do anything . Just give him a try.†(22) Lenny also cares a lot about George, George is perceived as Lennie’s role model. He tries to do things just like George and he does whatever George tells him. One time a bunch of people where down by the Sacramento River, and George turned to Lennie and said ,†Jump In.†(40) Lennie didn’t know how to swim and he almost drowned, but he jumped in just because George told him to. â€Å"Lennie coulda bust every bone in† Georges body â€Å" but Lennie never lifted a finger against â€Å" George.(40) Lennie is also very protective of George. One night all the bo ys on the ranch went into town except Lennie and Crooks, a black man who is the stable hand. Crooks wanted to mess with Lennie and asked him what would he do if George got hurt of killed that night. This made Lennie really mad that Crooks would even said that George would get hurt and he told Crooks,†Ain’t nobody goin’ to suppose no hurt to George.†(72)Lennie thinks the world of George and he doesn’t wanted anybody even thinking about hurting George. nbsp;nbsp;nbsp;nbsp;nbsp;The relationship between George and Lennie in the novel Of Mice and Men, shows how a true friendship should go. They were by eachShow MoreRelatedOf Mice and Men1242 Words   |  5 PagesOf Mice and Men Thomas Hobbes in his Leviathan states that, in the state of nature mans life is nasty, brutish and short. In depression era America, no greater truth could be said. There were millions unemployed, largely unskilled and living on the margins of society. The lowest of the low were the migrant labourers travelling from place to place trying to scratch a living. They often had to travel illegally by freight car with all its consequent dangers. Their life expectancy was low, crimeRead MoreOf Mice and Men961 Words   |  4 PagesPeople have a tendency to lose sight of their goals and dreams. Mentally, people struggle to maintain their sanity in this game of life that has no set of rules. In the book Of Mice and Men, this story portrays the inequality between people’s dreams and what can actually be accomplished. John Steinbeck, the author Of Mice and Men, utilizes his general themes of friendship and loneliness, through his deep characterization and connection between characters i n order to illustrate â€Å"The American dream.† TheRead MoreOf Mice and Men1352 Words   |  6 PagesOf Mice and Men Essay - Fate or Choice? Choice is defined by the ‘Shorter Oxford Dictionary’ as; â€Å"The act of choosing; preferential determination between things proposed.† It also states the definition for fate; â€Å"The principle, power, or agency by which events are unalterably predetermined from eternity.† Is our life choice, can we determine our fate by choosing our path or is our destiny determined for us? John Steinbeck puts forward this question in his novella Of Mice and MenRead MoreMice and men1998 Words   |  8 PagesHey this essay is about me not having one and just wanting a free account.GCSE JOHN STEINBECK The first 200 words of this essay... à ¯Ã‚ »Ã‚ ¿Of Mice and Men Essay à ¢Of Mice and Menà ¢ is the fictional short novel written by John Steinbeck in 1937. Steinbeckà ¢s perspective when writing the novel could be based on the fact that he had once worked on a ranch and had a certain fascination about it. The novel is set in 1930s America and this can be seen as the cause of the very enduring culmination that takesRead MoreOf Mice and Men1006 Words   |  5 Pagesheart of every novel.† In your view, what are the distinctive ideas explored in Of Mice and Men? Explain how these ideas are developed throughout the novel. Themes are integral and fundamental aspects which render the literature valuable. They usually provide insight into the author’s perception and internalisations of the world in which they live. Set in California during the Great Depression, Of Mice and Men, by Steinbeck, illustrates the hardships experienced by individuals as they roamed theRead MoreOF MICE AND MEN1721 Words   |  7 Pagesï » ¿In the book Of Mice and Men, the single women that appeared in the book resented herself as an object. The statement Women today are more often treated by men as equals rather than objects can be true or false. A man that goes to Gentleman s Cubs every night is a different man that studies at Harvard Law School. A striper is going to be a different person than a CEO of a successful business. It’s all about how you present yourself. In Of Mice and Men, Curley s wife presents herself in a seductiveRead MoreOf Mice and Men1035 Words   |  5 PagesFriendship of George and Lenny The book Of Mice and Men focuses on the friendship of two migrant workers in California at a time when most of the work was done by people and not by machines.  Ã‚  George was a small man who acted worldly and wise.  Ã‚  Lennie was a huge man that had the mind of a child.  Ã‚  Together George and Lennie would bounce from job to job with no money in their pockets and only the dream of someday owning a place of their own to keep them going.  Ã‚  The two men were not able to stay in one placeRead MoreOf Mice and Men547 Words   |  2 PagesJohn Steinbeck’s landmark novel Of Mice and Men is perhaps best known for its revolutionary telling of two characters that are very different, but have come to rely on each other to survive during the Great Depression. The two characters are men named George and Lenny. George is somewhat of an average fellow who has no real special skills or attributes. Lenny is large and abnormally strong, but unfortunately has the mind of a child. Le nnie looks up to George as if he were a role model. This statementRead MoreMice and Men822 Words   |  4 Pagesâ€Å"Of Mice and Men† The Great Depression took place in the United States in the 1930s. Northern California, Salinas Valley was affected by the Great Depression. Many farmers lost their properties and were forced to find other work. Banks were forced to foreclose on mortgages’ and had to collect debts. Hundreds of thousands of farmers packed up their families and few belongings, and headed for California. The Great Depression left many people in poverty and caused them to face unpleasant eventsRead MoreOf Mice and Men1171 Words   |  5 PagesOf Mice and Men by John Steinbeck Q- â€Å"I never seen no piece of jail bait worse than her† what is the reader supposed to think about Curley’s wife? * How is she described by the other characters? * How the author describes her * How she speaks/behaves * Her dreams * Is she the cause of all the trouble Written By Ruqayyah Draey Curley’s wife is not well described and respected by the other characters. She is often looked down upon and discriminated